Research Articles
Assessing Fusion Gene Detection Sensitivity of the AmpliSeq Childhood Cancer Panel: A Comprehensive Guide for Research and Diagnostic Applications
This article provides a comprehensive evaluation of the AmpliSeq™ for Illumina® Childhood Cancer Panel, a targeted NGS solution for fusion gene detection in pediatric and young adult cancers.
Amplicon Contamination: Sources, Prevention, and Decontamination Strategies for Research Laboratories
Amplicon contamination is a pervasive challenge in molecular biology, leading to false-positive results that can compromise research integrity and diagnostic accuracy.
Comparative Analysis of m6A-Related lncRNA Signatures: Prognostic and Therapeutic Implications Across Major Cancer Types
This review synthesizes the rapidly evolving field of N6-methyladenosine (m6A)-modified long non-coding RNAs (lncRNAs) and their utility as prognostic signatures across diverse cancers.
m6A-Related lncRNA Signatures: Outperforming Traditional Staging in Cancer Prognosis and Treatment
This article explores the transformative potential of m6A-related long non-coding RNA (lncRNA) signatures as a novel class of biomarkers in oncology.
Navigating Missing Data in m6A-lncRNA Multivariate Analysis: A Comprehensive Guide for Clinical and Translational Researchers
This article provides a comprehensive guide for researchers and drug development professionals on addressing the critical challenge of missing data in multivariate analyses of m6A-related long non-coding RNAs (lncRNAs).
Navigating Batch Effects in Multi-Cohort m6A-lncRNA Studies: A Comprehensive Guide from Discovery to Clinical Validation
The integration of multi-cohort data is paramount for validating robust m6A-related lncRNA signatures in cancer research, yet it is severely compromised by pervasive batch effects.
Evaluating Cathepsin B Inhibition Models: From Computational Screening to Therapeutic Applications in Cancer and Neurodegenerative Diseases
This comprehensive review systematically evaluates the performance of Recursive Feature Elimination (RFE) models in identifying and optimizing Cathepsin B inhibitors.
RFE vs. Correlation-Based Feature Selection: A Practical Guide for Molecular Data Analysis in Biomedicine
This article provides a comprehensive comparison of Recursive Feature Elimination (RFE) and correlation-based feature selection methods for high-dimensional molecular data.
A Comprehensive Guide to RFE Feature Selection for High-Dimensional Biological Data
This article provides a complete protocol for applying Recursive Feature Elimination (RFE) to high-dimensional biological datasets, a common challenge in genomics, transcriptomics, and drug discovery.
Recursive Feature Elimination (RFE) in Machine Learning: A Complete Guide for Biomedical Research
This comprehensive guide explores Recursive Feature Elimination (RFE), a powerful wrapper-style feature selection technique critical for handling high-dimensional data in biomedical research and drug development.